Effects of an Exercise and Diet-Induced Weight Loss Program on Resistin and Visfatin in Sedentary Obese Women Conference Paper uri icon


  • Resistin and visfatin are secreted by adipose tissue and potential regulators of inflammation and insulin sensitivity. This study examined the effects of exercise and dietinduced weight loss on resistin, visfatin and other adiposity and inflammatory markers. 26 sedentary obese women were randomly assigned into a control (C) or an exercise (E) group that involved circuit resistanceexercise (4 d/wk) with walking (10,000 steps/d, 3 d/wk) while consuming 1,200 kcal/day for 1wk and 1,500 kcal/d diet for 11 wks consisting of 45:30 % PRO:CHO. Baseline and posttraining DEXA body composition and fasting blood samples were obtained and analyzed by MANOVA and Pearson correlation analysis. Data are presented as meanSD changes from baseline. Participants in the E group lost more weight (E: 13.08.9; C: 1.43.1 lbs, p=0.001) and fat (E: 5.14.5; C:0.41.5 kg, p=0.001). Significant differences were seen between groups in leptin (E: 19.821.9; C: 4.516 ng/ml, p=0.003) while visfatin (E: 0.0915.4; C: 89.3177 ng/ml, p=0.095), IL6 (E: 38.946; C:264.4597 %, p=0.093), TNF (E: 1.5728; C: 96.9186 %, p=0.093), and insulin (E: 8.514.9; C:0.127.7 uIU/ml, p=0.070) tended to differ between groups and no differences were seen in resistin (E: 5.7126; C: 62.3162 ng/ml, p=0.25) or glucose (E: 3.819.8; C:2.86.9 %, p=0.87). Significant correlations were seen between changes in resistin and TNF (r = 0.49) while changes in visfatin correlated with changes in leptin (r=0.51) and IL6 (r=0.91). These findings indicate that exercise has beneficial effects on weight loss and body composition and this may adiposity and inflammatory markers.

published proceedings


author list (cited authors)

  • Khanna, D., Galvan, E., Baetge, C., Levers, K., Simbo, S., Byrd, M., ... Kreider, R.

citation count

  • 1

complete list of authors

  • Khanna, D||Galvan, E||Baetge, C||Levers, K||Simbo, S||Byrd, M||Jung, P||Koozehchian, M||Rasmussen, C||Greenwood, M||Kreider, R

publication date

  • April 2015