Investigation of pH and temperature on optical rotatory dispersion for noninvasive glucose monitoring Conference Paper uri icon

abstract

  • The widespread occurrence of diabetes mellitus and the severity of its associated complications necessitate the development of non-invasive blood glucose measurement devices in an attempt to improve treatment regiments and curb the complications associated with this disease. One method showing promise in this endeavor utilizes optical polarimetry to monitor blood glucose levels indirectly by measuring glucose rotation of polarized light, which is a direct indication of glucose concentration, in the aqueous humor of the eye. The presence of other optically active (chiral) components in the aqueous humor of the eye have the potential to confound the glucose measurement of optical rotation when using a single wavelength polarimeter. Thus, this has led to the recent investigation of multispectral polarimetric systems which have the potential to enable the removal of confounder contributions to the net observed optical rotation, therefore, increasing glucose specificity and reducing glucose prediction errors. Such polarimetric systems take advantage of the uniqueness in the rotation of polarized light, as a function of wavelength, by the chiral molecule of interest. This is commonly referred to as the optical rotatory dispersion (ORD) spectra of the chiral molecule. ORD characterization of the chiral molecules within the aqueous humor is necessary for determining the optimum number of wavelengths needed to reduce glucose prediction errors, however, this information is often only given at the sodium-D line (589nm) in the literature. This report describes the system we designed and built to measure ORD spectra for glucose and for albumin, the main optical confounder within the aqueous humor, as well as our investigation of the effects of temperature and pH on these ORD spectra.

name of conference

  • Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring

published proceedings

  • OPTICAL DIAGNOSTICS AND SENSING OF BIOLOGICAL FLUIDS AND GLUCOSE AND CHOLESTEROL MONITORING

author list (cited authors)

  • Baba, J. S., Meledeo, A., Cameron, B. D., & Cote, G. L.

citation count

  • 2

complete list of authors

  • Baba, JS||Meledeo, A||Cameron, BD||Cote, GL

editor list (cited editors)

  • Priezzhev, A. V., & Cote, G. L.

publication date

  • January 2001