Application of surface-enhanced Raman spectroscopy for detection of beta amyloid using nanoshells Academic Article uri icon


  • Currently, no methods exist for the definitive diagnosis of AD premortem. -amyloid, the primary component of the senile plaques found in patients with this disease, is believed to play a role in its neurotoxicity. We are developing a nanoshell substrate, functionalized with sialic acid residues to mimic neuron cell surfaces, for the surface-enhanced Raman detection of -amyloid. It is our hope that this sensing mechanism will be able to detect the toxic form of -amyloid, with structural and concentration information, to aid in the diagnosis of AD and provide insight into the relationship between -amyloid and disease progression. We have been successfully able to functionalize the nanoshells with the sialic acid residues to allow for the specific binding of -amyloid to the substrate. We have also shown that a surface-enhanced Raman spectroscopy response using nanoshells is stable and concentration-dependent with detection into the picomolar range. Springer Science+Business Media, LLC 2007.

published proceedings


altmetric score

  • 3

author list (cited authors)

  • Beier, H. T., Cowan, C. B., Chou, I., Pallikal, J., Henry, J. E., Benford, M. E., ... Cote, G. L.

citation count

  • 59

complete list of authors

  • Beier, Hope T||Cowan, Christopher B||Chou, I-Hsien||Pallikal, James||Henry, James E||Benford, Melodie E||Jackson, Joseph B||Good, Theresa A||Cote, Gerard L

publication date

  • January 2007