Detection of integrins using surface enhanced Raman Spectroscopy Conference Paper

abstract

• Integrins play an important role in the adhesion of cells to extracellular matrix and to other cells around them, more specifically fibronectin. The ultimate goal of this research is to detect these integrins on the surface of the cell with a combined atomic force microscopy (AFM) system coupled with a surface enhanced Raman spectroscopy (SERS) system. For this paper the focus was on identifying whether SERS is capable of being used to generate a unique spectrum for integrins. This was done using silver colloidal particles and the integrins 51 and V3. It was shown that a unique spectrum could be identified for each of these integrins at the nanomolar level.

name of conference

• Optical Diagnostics and Sensing IV

authors

• Cote, Gerard

published proceedings

• OPTICAL DIAGNOSTICS AND SENSING IV

author list (cited authors)

• Gant, V. A., Chowdury, M. H., Meininger, G. A., & Cote, G. L.

citation count

• 0

complete list of authors

• Gant, VA||Chowdury, MH||Meininger, GA||Cote, GL

editor list (cited editors)

• Cote, G. L., & Priezzhev, A. V.

publication date

• June 2004

publisher

• SPIE, the international society for optics and photonics  Publisher

published in

• Proceedings of SPIE  Journal

keywords

• Afm
• Atomic Force Microscope
• Integrin
• Surface Enhanced Raman Spectroscopy

Digital Object Identifier (DOI)

• 10.1117/12.535344

International Standard Book Number (ISBN) 10

• 0-8194-5233-5

URI

• https://hdl.handle.net/1969.1/2304

start page

• 174

end page

• 178

volume

• 5325

URL

• http%3A%2F%2Fdx.doi.org%2F10.1117%2F12.535344