A new twist on clock protein phosphorylation: a conformational change leads to protein degradation. Academic Article uri icon


  • Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth etal. (2011) demonstrate that phosphorylation of Neurospora FRQ inducesa conformational change, which can account for its temporally gated degradation.

published proceedings

  • Mol Cell

altmetric score

  • 0.5

author list (cited authors)

  • Menet, J. S., & Rosbash, M.

citation count

  • 11

complete list of authors

  • Menet, Jerome S||Rosbash, Michael

publication date

  • January 2011