A new twist on clock protein phosphorylation: a conformational change leads to protein degradation.
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Progressive phosphorylation of circadian clock proteins is a hallmark of time-keeping. In this issue of Molecular Cell, Querfurth etal. (2011) demonstrate that phosphorylation of Neurospora FRQ inducesa conformational change, which can account for its temporally gated degradation.
author list (cited authors)
Menet, J. S., & Rosbash, M.
complete list of authors
Menet, Jerome S||Rosbash, Michael