A Nickel-Based, Tandem Catalytic Approach to Isoindolinones from Imines, Aryl Iodides, and CO Academic Article

abstract

• 2015 American Chemical Society. We describe herein a modular nickel-catalyzed synthesis of isoindolinones from imines, aryl iodides, and CO. This reaction is catalyzed by Ni(1,5-cyclooctadiene)2 in concert with chloride salts and postulated to proceed via a tandem nickel-catalyzed carbonylation to form N-acyl iminium chloride salts, followed by a spontaneous nickel-catalyzed cyclization. A range of aryl iodides and imines have been found to be viable substrates in this reaction, providing a modular route to generate substituted isoindolinones with high atom economy.

authors

• Bengali, Ashfaq

published proceedings

• ORGANOMETALLICS

altmetric score

• 0.25

author list (cited authors)

• Tjutrins, J., Shao, J. L., Yempally, V., Bengali, A. A., & Arndtsen, B. A.

citation count

• 26

complete list of authors

• Tjutrins, Jevgenijs||Shao, Jia Lun||Yempally, Veeranna||Bengali, Ashfaq A||Arndtsen, Bruce A

publication date

• January 2015

publisher

• American Chemical Society (ACS)  Publisher

published in

• Organometallics  Journal

keywords

• Biotechnology

Digital Object Identifier (DOI)

• 10.1021/acs.organomet.5b00215

start page

• 1802

end page

• 1805

volume

• 34

issue

• 10

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Facs.organomet.5b00215