A Nickel-Based, Tandem Catalytic Approach to Isoindolinones from Imines, Aryl Iodides, and CO Academic Article uri icon

abstract

  • © 2015 American Chemical Society. We describe herein a modular nickel-catalyzed synthesis of isoindolinones from imines, aryl iodides, and CO. This reaction is catalyzed by Ni(1,5-cyclooctadiene)2 in concert with chloride salts and postulated to proceed via a tandem nickel-catalyzed carbonylation to form N-acyl iminium chloride salts, followed by a spontaneous nickel-catalyzed cyclization. A range of aryl iodides and imines have been found to be viable substrates in this reaction, providing a modular route to generate substituted isoindolinones with high atom economy.

altmetric score

  • 0.25

author list (cited authors)

  • Tjutrins, J., Shao, J. L., Yempally, V., Bengali, A. A., & Arndtsen, B. A.

citation count

  • 17

publication date

  • May 2015