The value of mentoring for career development is widely recognized by researchers and practitioners. For women, being mentored is particularly valuable for their career growth. However, the reality is that professional women continue to encounter challenges men do not, both in finding mentors and in building healthy mentoring relationships. In this chapter, the authors examine how e-mentoring can be used as an alternative tool to address some of the challenges facing women in mentoring relationships and to assist them with their career progression. They conduct an integrative literature review to identify research on e-mentoring in the context of women's career development, and they identify trends in current e-mentoring research and make recommendations for improving e-mentoring practice. The chapter concludes with directions for future research on e-mentoring.