Assignment of terminal penalties in controlling genetic regulatory networks Conference Paper

abstract

• Probabilistic Boolean Networks have been used to model inter gene relationships and their dynamic behavior. Optimal control of such networks has been proposed by turning on or off individual genes. Though this problem was solved in an earlier work by using a dynamic programming algorithm, issues regarding the assignment of terminal penalties and selection of genes for intervention were not addressed. In this work we provide an algorithm for assigning terminal penalties, taking long term uncontrolled behavior into account. We also discuss the possibility of using gene influence for pre selection of genes to be used for intervention. This is implemented for the popular WNT5A network. 2005 AACC.

name of conference

• Proceedings of the 2005, American Control Conference, 2005.

authors

• Datta, Aniruddha
• Dougherty, Edward

published proceedings

• ACC: PROCEEDINGS OF THE 2005 AMERICAN CONTROL CONFERENCE, VOLS 1-7

author list (cited authors)

• Choudhary, A., Datta, A., Bittner, M. L., & Dougherty, E. R.

citation count

• 7

complete list of authors

• Choudhary, A||Datta, A||Bittner, ML||Dougherty, ER

publication date

• January 2005

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

published in

• Proceedings of the ... American Control Conference. American Control Conference  Journal

keywords

• 31 Biological Sciences
• 3102 Bioinformatics And Computational Biology
• Genetics
• Prevention

Digital Object Identifier (DOI)

• 10.1109/ACC.2005.1469971

International Standard Book Number (ISBN) 10

• 0-7803-9098-9

start page

• 417

end page

• 422

volume

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1109%2Facc.2005.1469971