Optimal Intervention Strategies for Cyclic Therapeutic Methods with Fixed-Length Duration of Effect Conference Paper uri icon


  • When implementing chemotherapy, it is possible to decrease the likelihood of visiting undesirable states by finding the right dose schedules that maximizes the benefit to toxicity ratio of a delivered drug. Therapies in a typical practice are usually administered in cycles. If treatment is applied at the beginning of a cycle, then the patient will be under the influence of the drug for some period of time, after which there can be a recovery phase. In this paper, we present a methodology to devise optimal intervention policies in Markovian genetic regulatory networks for the class of cyclic therapeutic methods where interventions have fixed-length duration of effectiveness. © 2011 IEEE.

author list (cited authors)

  • Yousefi, M. R., Datta, A., & Dougherty, E. R.

citation count

  • 1

publication date

  • November 2011