Optimal intervention strategies for cyclic therapeutic methods with fixed-length duration of effect Conference Paper uri icon


  • When implementing chemotherapy, it is possible to decrease the likelihood of visiting undesirable states by finding the right dose schedules that maximizes the benefit to toxicity ratio of a delivered drug. Therapies in a typical practice are usually administered in cycles. If treatment is applied at the beginning of a cycle, then the patient will be under the influence of the drug for some period of time, after which there can be a recovery phase. In this paper, we present a methodology to devise optimal intervention policies in Markovian genetic regulatory networks for the class of cyclic therapeutic methods where interventions have fixed-length duration of effectiveness. 2011 IEEE.

name of conference

  • 2011 45th Asilomar Conference on Signals, Systems and Computers

published proceedings

  • 2011 Conference Record of the Forty Fifth Asilomar Conference on Signals, Systems and Computers (ASILOMAR)

author list (cited authors)

  • Yousefi, M. R., Datta, A., & Dougherty, E. R.

citation count

  • 1

complete list of authors

  • Yousefi, Mohammadmahdi R||Datta, Aniruddha||Dougherty, Edward R

publication date

  • November 2011