Assessing the Efficacy of Molecularly Targeted Agents by Using Kalman Filter Conference Paper uri icon

abstract

  • A novel preclinical model combining experimental methods and theoretical analysis is proposed to investigate the mechanism of action and identify pharmacodynamic characteristic of a drug. Instead of fixed time point analysis of the drug exposure to drug effect, the time course of drug effect for different doses are quantitatively studied on cell line-based platforms using Kalman filter, where tumor cells' responses to drugs through the use of fluorescent reporters are sampled frequently over a time-course. It is expected that such preclinical study will provide valuable suggestions about dosing regimens for in vivo experimental stage to increase productivity. 2011 IEEE.

name of conference

  • 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

published proceedings

  • 2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)

author list (cited authors)

  • Li, X., Qian, L., Bittner, M. L., & Dougherty, E. R.

citation count

  • 2

complete list of authors

  • Li, Xiangfang||Qian, Lijun||Bittner, Michael L||Dougherty, Edward R

publication date

  • December 2011