Assessing the Efficacy of Molecularly Targeted Agents by Using Kalman Filter
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abstract
A novel preclinical model combining experimental methods and theoretical analysis is proposed to investigate the mechanism of action and identify pharmacodynamic characteristic of a drug. Instead of fixed time point analysis of the drug exposure to drug effect, the time course of drug effect for different doses are quantitatively studied on cell line-based platforms using Kalman filter, where tumor cells' responses to drugs through the use of fluorescent reporters are sampled frequently over a time-course. It is expected that such preclinical study will provide valuable suggestions about dosing regimens for in vivo experimental stage to increase productivity. 2011 IEEE.
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2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)