Multiple Reaction Monitoring: Modeling and Systematic Analysis
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abstract
Mass Spectrometry in Multiple Reaction Monitoring (MRM) mode is becoming increasingly used in the validation of protein biomarkers. In a systematic approach toward studying MRM, in this paper, the biomarker validation pipeline using this method is modeled. Numerical experiments based on this model are used to study the effect of different parameters on the final performance of biomarker validation. 2011 IEEE.
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2011 IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS)