Polyphosphoramidates That Undergo Acid-Triggered Backbone Degradation
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2017 American Chemical Society. The direct and facile synthesis of polyphosphoramidates (PPAs) with acid-labile phosphoramidate backbone linkages are reported, together with demonstration of their hydrolytic degradability, evaluated under acidic conditions. The introduction of acid-labile linkages along the polymer backbone led to rapid degradation of the polymer backbone dependent upon the environmental stimuli. An oxazaphospholidine monomer bearing a phosphoramidate linkage was designed and synthesized to afford the PPAs via organobase-catalyzed ring-opening polymerization in a controlled manner. The hydrolytic degradation of the PPAs was studied, revealing breakdown of the polymer backbone through cleavage of the phosphoramidate linkages under acidic conditions.
author list (cited authors)
Wang, H., Su, L. u., Li, R., Zhang, S., Fan, J., Zhang, F., Nguyen, T. P., & Wooley, K. L.
complete list of authors
Wang, Hai||Su, Lu||Li, Richen||Zhang, Shiyi||Fan, Jingwei||Zhang, Fuwu||Nguyen, Tan P||Wooley, Karen L