Polyphosphoramidates That Undergo Acid-Triggered Backbone Degradation. Academic Article uri icon


  • The direct and facile synthesis of polyphosphoramidates (PPAs) with acid-labile phosphoramidate backbone linkages are reported, together with demonstration of their hydrolytic degradability, evaluated under acidic conditions. The introduction of acid-labile linkages along the polymer backbone led to rapid degradation of the polymer backbone dependent upon the environmental stimuli. An oxazaphospholidine monomer bearing a phosphoramidate linkage was designed and synthesized to afford the PPAs via organobase-catalyzed ring-opening polymerization in a controlled manner. The hydrolytic degradation of the PPAs was studied, revealing breakdown of the polymer backbone through cleavage of the phosphoramidate linkages under acidic conditions.

published proceedings

  • ACS Macro Lett

author list (cited authors)

  • Wang, H., Su, L. u., Li, R., Zhang, S., Fan, J., Zhang, F., Nguyen, T. P., & Wooley, K. L.

citation count

  • 22

complete list of authors

  • Wang, Hai||Su, Lu||Li, Richen||Zhang, Shiyi||Fan, Jingwei||Zhang, Fuwu||Nguyen, Tan P||Wooley, Karen L

publication date

  • March 2017