The origin of the biphasic flow response to local heat in skin. Academic Article uri icon


  • OBJECTIVE: Although it is well established that the application of local heat causes a biphasic increase in skin blood flow, the responsible microvessels have not been identified. METHODS: A bifurcating network of arterioles (1st-5th orders, 60-15 mum, n = 10 per group) of the intact, unanesthetized, translucent bat wing were visualized on a transparent heat plate via intravital microscopy. Similar to previous bat wing studies, plate temperature was set at 25 degrees C for 10 min then increased to 37 degrees C for 20 min. Vessel diameter and red blood cell velocity were recorded and used to calculate resistance and blood flow. RESULTS: The average flow response in arterioles was biphasic (p = 0.02) and proportional to the temporal decrease in total resistance calculated from 1st-5th order arterioles. Metarteriole (i.e., 5th order arteriole) resistance had the greatest impact on total resistance (-67.0 +/- 20.7%) and exhibited a biphasic trend that was opposed by temporal changes in resistance of 1st-4th order arterioles. CONCLUSION: Metarterioles are not only necessary but sufficient to explain the origin of the biphasic flow response in skin blood flow.

published proceedings

  • Microcirculation

altmetric score

  • 3

author list (cited authors)

  • Widmer, R. J., Laurinec, J. E., Young, M. F., Mohiuddin, M. W., Laine, G. A., & Quick, C. M.

citation count

  • 7

complete list of authors

  • Widmer, R Jay||Laurinec, Jennifer E||Young, Missy F||Mohiuddin, M Waqar||Laine, Glen A||Quick, Christopher M

publication date

  • May 2008