Social stress alters the severity and onset of the chronic phase of Theiler's virus infection. Academic Article

abstract

• Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.

authors

• Meagher, Mary
• Welsh, Christabel Jane
• Welsh, Thomas

published proceedings

• J Neuroimmunol

author list (cited authors)

• Johnson, R. R., Prentice, T. W., Bridegam, P., Young, C. R., Steelman, A. J., Welsh, T. H., Welsh, C., & Meagher, M. W.

citation count

• 28

complete list of authors

• Johnson, Robin R||Prentice, Thomas W||Bridegam, Patrick||Young, Colin R||Steelman, Andrew J||Welsh, Thomas H||Welsh, C Jane R||Meagher, Mary W

publication date

• January 2006

publisher

• Elsevier  Publisher

published in

• JOURNAL OF NEUROIMMUNOLOGY  Journal

keywords

• Acute Disease
• Animals
• Behavior, Animal
• Cardiovirus Infections
• Chronic Disease
• Male
• Mice
• Mice, Inbred BALB C
• Multiple Sclerosis
• Severity Of Illness Index
• Social Behavior
• Stress, Psychological
• Theilovirus

Digital Object Identifier (DOI)

• 10.1016/j.jneuroim.2006.02.014

start page

• 39

end page

• 51

volume

• 175

issue

• 1-2

URL

• http://dx.doi.org/10.1016/j.jneuroim.2006.02.014

user-defined tag

• 3 Good Health and Well-Being