CARS microscopy studies of collagen transformation
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abstract
Nonlinear Raman spectroscopy is employed to study structural transformation of collagen (type I) in solution. Relatively strong signal and polarization background suppression reveal significant changes of the vibrational spectrum of collagen, which are attributed to the formation of cholesteric globules. Circular dichroism spectroscopy confirms the concentration dependent structural transformation. Excellent axial resolution achieved in nonlinear Raman microscopy also allows to study for the first time the effect of large molecule adhesion on the surface.
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Multiphoton Microscopy in the Biomedical Sciences V