Probing axial orientation of collagen fibers with Brillouin microspectroscopy
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2015 SPIE. Collagen is an important structural component in many biological tissues including bone, teeth, skin, and vascular endothelial layer. Its fibrillar arrangement can produce tissues with distinct anisotropies and is responsible for its unique elastic properties. However, current methods of retrieving orientation of those fibers show low sensitivity to the out-of-plane orientations. In this report, we employed Brillouin microspectroscopy to probe the local sound velocity, which, in its turn, is found to have a strong correlation to the local fibrillar arrangements.
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Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXII