Towards noninvasive drug distribution in tissues: coherent Raman microspectroscopy of chiral molecules Conference Paper uri icon

abstract

  • 2017 SPIE. Many biologically active molecules are chiral. Many drugs, which are currently in use, are supplied as an equimolar mixture of enantiomers. Although they have the same chemical structure, i.e. are not distinguishable by conventional Raman spectroscopy, most isomers of chiral drugs exhibit marked differences in biological activities such as pharmacology, toxicology, pharmacokinetics, metabolism, etc. In this report we introduced a new spectroscopic tool to extend nonlinear Raman spectroscopy to chiral substances.

name of conference

  • Visualizing and Quantifying Drug Distribution in Tissue

published proceedings

  • VISUALIZING AND QUANTIFYING DRUG DISTRIBUTION IN TISSUE

author list (cited authors)

  • Petrov, G. I., & Yakovlev, V. V.

citation count

  • 1

complete list of authors

  • Petrov, Georgi I||Yakovlev, Vladislav V

editor list (cited editors)

  • Chan, K. F., & Evans, C. L.

publication date

  • February 2017