Three-dimensional organization of block copolymers on "DNA-minimal" scaffolds. Academic Article uri icon


  • Here, we introduce a 3D-DNA construction method that assembles a minimum number of DNA strands in quantitative yield, to give a scaffold with a large number of single-stranded arms. This DNA frame is used as a core structure to organize other functional materials in 3D as the shell. We use the ring-opening metathesis polymerization (ROMP) to generate block copolymers that are covalently attached to DNA strands. Site-specific hybridization of these DNA-polymer chains on the single-stranded arms of the 3D-DNA scaffold gives efficient access to DNA-block copolymer cages. These biohybrid cages possess polymer chains that are programmably positioned in three dimensions on a DNA core and display increased nuclease resistance as compared to unfunctionalized DNA cages.

published proceedings

  • J Am Chem Soc

altmetric score

  • 6

author list (cited authors)

  • McLaughlin, C. K., Hamblin, G. D., Hnni, K. D., Conway, J. W., Nayak, M. K., Carneiro, K., Bazzi, H. S., & Sleiman, H. F.

citation count

  • 71

complete list of authors

  • McLaughlin, Christopher K||Hamblin, Graham D||Hänni, Kevin D||Conway, Justin W||Nayak, Manoj K||Carneiro, Karina MM||Bazzi, Hassan S||Sleiman, Hanadi F

publication date

  • March 2012