The effects of in vitro incubation with acetylsalicylic acid on thrombocyte aggregation in whole blood from normal ostriches Academic Article

abstract

• Avian thrombocytes are circulating nucleated blood cells which play an active role in both haemostasis and phagocytosis. To better define their role in haemostasis, thrombocyte aggregation was measured in whole blood from healthy adult ostriches using an electrical impedance aggregometer. Thrombocytes were stimulated with collagen (5 g/ml or 1 g/ml), platelet-activating factor (PAF (0.1 M, 0.01 M, or 0.001 M), or ADP (25 M). Irreversible aggregation occurred consistently in response to collagen or PAF but not to ADP. Aggregation in response to high concentrations of PAF or collagen was not affected by in vitro incubation with 500 M aspirin. Aggregation in response to low concentrations of PAF or collagen was partially inhibited by in vitro incubation with 500 M aspirin, suggesting the presence of a prostaglandin-dependent mechanism for regulation of thrombocyte activation similar to that in mammalian platelets.

authors

• Blue-Mclendon, Alice

published proceedings

• COMPARATIVE HAEMATOLOGY INTERNATIONAL

author list (cited authors)

• Thomas, J. S., & Blue-McLendon, A.

citation count

• 0

complete list of authors

• Thomas, JS||Blue-McLendon, A

publication date

• September 1998

publisher

• Springer Nature  Publisher

keywords

• Aggregation
• Aspirin
• Collagen
• Ostrich
• Platelet Activating Factor

Digital Object Identifier (DOI)

• 10.1007/BF02642504

start page

• 137

end page

• 141

volume

• 8

issue

• 3

URL

• http%3A%2F%2Fdx.doi.org%2F10.1007%2Fbf02642504