Probing the role of the bridging C509 between the [ Fe4S4 ] cubane and the [Ni p Ni d ] centre in the A-cluster of acetyl-coenzyme A synthase Academic Article uri icon


  • The A-cluster of acetyl-coenzyme A synthase consists of an [Fe(4)S(4)] cubane bridged to a [Ni(p)Ni(d)] centre via C509 cysteinate. The bridging cysteinate, which could be substituted by histidine imidazole, mediates "communication" between the [Fe(4)S(4)] cubane and the [Ni(p)Ni(d)] centre during the synthesis of acetyl-coenzyme A.

author list (cited authors)

  • Liu, Y. i., Zhu, X., Wang, F., Ying, T., Li, P., Huang, Z., & Tan, X.

citation count

  • 4

publication date

  • January 2011