Insights into the mechanistic role of the [Fe4S4] cubane in the A-cluster {[Fe4S4]-(SR)-[NipNid]} of acetyl-coenzyme A synthase. Academic Article uri icon

abstract

  • Cubane revolution: We have constructed various mutants to probe the role of [Fe4S4] cubane. The results show that [Fe4S4] cubane, which is bridged to a [NipNid] center via Cys509 cysteinate in the A-cluster of acetyl-coenzyme A synthase (see figure), modulates the redox properties of the catalytic metal Nip and stabilizes the low valence of Nip through the {[Fe4S4]-(SR)-Nip} "conjugation system". 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

published proceedings

  • Chembiochem

author list (cited authors)

  • Liu, Y. i., Wang, F., Li, P., & Tan, X.

citation count

  • 5

complete list of authors

  • Liu, Yi||Wang, Feng||Li, Pingwei||Tan, Xiangshi

publication date

  • June 2011

publisher