Intestinal adaptation in short bowel syndrome. Academic Article

abstract

• Regaining enteral autonomy after extensive small bowel resection is dependent on intestinal adaptation. This adaptational process is characterized by hyperplastic growth of the remaining gut, which is accompanied by both an increase of cell division at the level of the crypt cells and by an increased rate of programmed cell death (apoptosis). Apart from the absorptive function, the small bowel also has a barrier function and plays an important role in interorgan metabolism. Also, these functions are greatly affected by a massive intestinal resection and subsequent recovery by intestinal adaptation. This review aims to give an overview of the debilitating effects of massive intestinal resection on gut function and subsequently discusses intestinal adaptation and possible factors stimulating adaptation.

authors

• Deutz, Nicolaas

published proceedings

• ANZ J Surg

author list (cited authors)

• Welters, C., Dejong, C., Deutz, N., & Heineman, E.

citation count

• 44

complete list of authors

• Welters, Carlo FM||Dejong, Cornelius HC||Deutz, Nicolaas EP||Heineman, Erik

publication date

• March 2002

publisher

• Wiley  Publisher

published in

• n1445-1433ISSN  Journal

keywords

• Adaptation, Physiological
• Humans
• Recovery Of Function
• Short Bowel Syndrome

PubMed Central ID

• 12071459

Digital Object Identifier (DOI)

• 10.1046/j.1445-2197.2002.02357.x

start page

• 229

end page

• 236

volume

• 72

issue

• 3

URL

• http://dx.doi.org/10.1046/j.1445-2197.2002.02357.x