Effect of prolonged hyperdynamic endotoxemia on jejunal motility in fasted and enterally fed pigs. Academic Article uri icon

abstract

  • OBJECTIVE: To determine the effects of hyperdynamic endotoxemia on the motility of the small intestine. SUMMARY BACKGROUND DATA: Motility disorders of the gastrointestinal tract are a common complication of sepsis. It has been suggested that gram-negative endotoxin plays a role in the pathogenesis of the accompanying diarrhea frequently observed. METHODS: Pigs were infused with lipopolysaccharide for a 24-hour period. During this fasting period jejunal motility was measured using ambulatory manometry. One and 4 days after cessation of endotoxin, pigs were enterally fed, and again motility was recorded. RESULTS: Hyperdynamic endotoxemia was achieved in this model. Manometric pressure recordings revealed that endotoxin infusion accelerated the migrating motor complex (MMC) migration along the jejunum. Also, a simultaneous increase in MMC cycling frequency was observed in the endotoxin-treated group. Elevated MMC migration velocity and cycling frequency were maintained the following day after endotoxin during feeding and returned to basal values 4 days after endotoxin. CONCLUSIONS: A small dose of continuously infused endotoxin significantly provokes jejunal motility disturbances that may contribute to diarrhea.

published proceedings

  • Ann Surg

author list (cited authors)

  • Bruins, M. J., Luiking, Y. C., Soeters, P. B., Akkermans, L., & Deutz, N.

citation count

  • 13

complete list of authors

  • Bruins, Maaike J||Luiking, Yvette C||Soeters, Peter B||Akkermans, Louis MA||Deutz, Nicolaas EP

publication date

  • January 2003