Multi-compartment CNS neuron-glia co-culture platform Conference Paper

abstract

• A multi-compartment neuron co-culture platform for axon/glia interaction studies has been designed and fabricated using a newly developed hybrid macro/micro fabrication technique. The technique enables fabricating both macro/micro scale structures from a single master mold for high-throughput replication of microdevices by one-step PDMS soft-lithography process. Each compartment in the co-culture platform is fluidically isolated from each others to carry out multiple conditions of experiments in parallel. Neurons and oligodendrocytes (OLs) were successfully cocultured inside the device for up to four weeks with OLs expressing myelin basic protein on top of axonal layer inside the axon/glia compartments. 2009 CBMS.

authors

• Han, Arum
• Li, Jianrong

published proceedings

• Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

author list (cited authors)

• Park, J., Koito, H., Li, J., & Han, A.

complete list of authors

• Park, J||Koito, H||Li, J||Han, A

publication date

• January 2009

International Standard Book Number (ISBN) 13

• 9780979806421

start page

• 1318

end page

• 1320