Neuron aggregate culture platform for in vitro cns myelination study Conference Paper uri icon


  • A cell culture platform for neuron aggregates has been designed and fabricated as an in vitro model for studying CNS myelination. The device is composed of nine culture chambers each of which has 55 cell trapping sites for culturing neuron aggregates in a spatially controlled environments in parallel. Neuron aggregates prepared from embryonic day 16 rat fetus were cultured with oligodendrocyte progenitor cells (OPCs) and showed successful growth inside the device. Neuron aggregates formed intense axonal network with neighboring aggregates and OPCs differentiated into mature oligodendrocytes, expressing myelin basic protein.

published proceedings

  • 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010

author list (cited authors)

  • Park, J., Koito, H., Li, J., & Han, A.

complete list of authors

  • Park, J||Koito, H||Li, J||Han, A

publication date

  • December 2010