Beta-1,3-glucan effect on sow antibody production and passive immunisation of progeny
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abstract
-glucans are glucose homopolymers known to modulate immunity. Here, the -glucan effect on sow antibody production and passive immunisation of neonatal pigs was analysed. Treatments included: (1) corn-soy fed Control group; (2) -glucan; (3) Actinobacillus pleuropneumoniae (App) vaccination; and (4) -glucan App vaccination. Birth and weaning weights were not affected (P 0.05) by treatment. Independent of treatment, IgA, IgG and IgM in colostrum were elevated and declined rapidly. Vaccination against App resulted in an increase (PB0.05) in IgG and IgA specific for App serotypes 1, 5 and 7 in colostrum and milk, and a corresponding increase (PB0.05) in serum in pigs at 4 d of age. However, -glucan did not enhance specific App antibodies in pig serum. While the dosage used here did not enhance passive immunisation in pigs, -glucan can be potentially efficacious as an oral adjuvant to enhance immunoglobulin production in response to vaccination. 2009 Taylor & Francis.