Disposition of amikacin in fallow deer (Dama dama) following a single intramuscular dose

Single-dose pharmacokinetics of amikacin following i.m. administration were determined in six adult fallow deer (Dama dama). A dose of 7.47 0.71 mg/kg was determined by metabolic scaling. Serial blood samples were collected through an indwelling jugular catheter at 0, 5, 15, 30, 45, 60, 75, and 90 min and 2, 4, 5, 6, 8, 10, and 12 hr postadministration. Drug concentration vs. time curves were best fit to a biexponential equation, which was interpreted as a single compartment open model with first-order input. Maximal serum concentrations of 34.99 9.93 g/ml were reached at 0.40 0.21 hours based on a disappearance rate constant of 0.57 0.11 hr-1 and a model-dependent disappearance half-life of 1.14 0.051 hr. Model-independent parameters were mean residence time (1.62 0.32 hr), area under the curve (70.32 8.14 g[hr]/ml), area under the moment curve (115.8 8.29 g[hr]2/ml), average concentration at steady state (20.41 1.37 g/ml), and effective half-life (1.16 0.20 hr). Based on the minimum inhibitory concentration of typical organisms, the suggested dosing regimen for fallow deer is 7.5 mg/kg every 4-6 hr, depending on the organism encountered. Copyright 1996 by American Association of Zoo Veterinarians.

Overview