Sequence of the coding region of the bovine fibrillin cDNA and localization to bovine chromosome 10. Academic Article

abstract

• We report the cDNA sequence for the bovine gene for fibrillin corresponding to the human gene, fibrillin 1 (FBN1), and the localization of the gene to bovine chromosome 10 (syntenic group U5). The identity between the human and bovine sequences is 97.8% at the amino acid level and 92% at the nucleotide level. The bovine fibrillin sequence contains the same number and type of motifs as the human FBN1 sequence, including the same number of putative calcium binding sites. All of the motifs conform to the patterns demonstrated in the human sequence, and many of the differences in identity between the sequences are conservative.

authors

• Womack, James

published proceedings

• Genomics

author list (cited authors)

• Tilstra, D. J., Li, L., Potter, K. A., Womack, J., & Byers, P. H.

citation count

• 14

complete list of authors

• Tilstra, DJ||Li, L||Potter, KA||Womack, J||Byers, PH

publication date

• September 1994

publisher

• Elsevier  Publisher

published in

• Genomics  Journal

keywords

• Amino Acid Sequence
• Animals
• Base Sequence
• Cattle
• Chromosome Mapping
• DNA Primers
• DNA, Complementary
• Disease Models, Animal
• Fibrillin-1
• Fibrillins
• Humans
• Marfan Syndrome
• Mice
• Microfilament Proteins
• Molecular Sequence Data
• Sequence Homology, Amino Acid
• Species Specificity

PubMed Central ID

• 7835900

Digital Object Identifier (DOI)

• 10.1006/geno.1994.1527

start page

• 480

end page

• 485

volume

• 23

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1006%2Fgeno.1994.1527