Use of avian bornavirus isolates to induce proventricular dilatation disease in conures. Academic Article uri icon


  • Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). We successfully isolated and characterized ABV from the brains of 8 birds with confirmed PDD. One isolate was passed 6 times in duck embryo fibroblasts, and the infected cells were then injected intramuscularly into 2 healthy Patagonian conures (Cyanoliseus patagonis). Clinical PDD developed in both birds by 66 days postinfection. PDD was confirmed by necropsy and histopathologic examination. Reverse transcription-PCR showed that the inoculated ABV was in the brains of the 2 infected birds. A control bird that received uninfected tissue culture cells remained healthy until it was euthanized at 77 days. Necropsy and histopathologic examinations showed no abnormalities; PCR did not indicate ABV in its brain tissues.

published proceedings

  • Emerg Infect Dis

altmetric score

  • 3

author list (cited authors)

  • Gray, P., Hoppes, S., Suchodolski, P., Mirhosseini, N., Payne, S., Villanueva, I., ... Tizard, I.

citation count

  • 89

complete list of authors

  • Gray, Patricia||Hoppes, Sharman||Suchodolski, Paulette||Mirhosseini, Negin||Payne, Susan||Villanueva, Itamar||Shivaprasad, HL||Honkavuori, Kirsi S||Lipkin, W Ian||Briese, Thomas||Reddy, Sanjay M||Tizard, Ian

publication date

  • March 2010