Nonlinear optical spectroscopy of collagen transformation
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abstract
We report on the novel application of nonlinear optics to study molecular assemblies. By using the third-harmonic generation in solution we were able to determine both the third-order nonlinear susceptibility of collagen and the size of fibrils. The developed approach also helped us in revealing the helix-coil transformation of collagen in solution.
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Multiphoton Microscopy in the Biomedical Sciences IV