Role of Age-Dependent Changes in MMP Expression in Acute Kidney Injury Conference Paper uri icon


  • Aging is associated with an increased incidence and severity of acute renal failure. However, the molecular mechanism(s) underlying the increased susceptibility to injury remain undefined. Given the emerging role of MMPs in ischemic renal injury, the renal mRNA expression of MMPs and their endogenous inhibitors, TIMPs (tissue inhibitor of metalloproteinases), were also examined in young, agedAL and agedCR rats. Interestingly, agedependent increases in the expression of MMP7, 9, 13, and 14 were seen, and these changes were attenuated by caloric restriction. The expression of TIMP1, but not TIMP2 or 3, was increased by age and attenuated by caloric restriction. Changes in MMP expression gene expression were paralleled by an agedependent increase in collagenase, gelatinase, and membrane typeMMP activity. Specific increases in MMP7, 9, and 13 activity was seen in urine and kidney tissue, respectively. These results suggest an association between the agerelated increase in susceptibility to injury and overexpression of select MMPs (7, 9, 13, and 14) in the kidney, implying a therapeutic potential for inhibition of these MMPs in acute kidney injury.

published proceedings


author list (cited authors)

  • Akintola, A. D., Chen, G., Catania, J. M., Burghardt, R. C., & Parrish, A. R.

citation count

  • 0

complete list of authors

  • Akintola, Adebayo D||Chen, Gang||Catania, Jeffrey M||Burghardt, Robert C||Parrish, Alan R

publication date

  • March 2008