FGF-2 induces regeneration of the chick limb bud. Academic Article

abstract

• The chick limb bud is unable to mount a regenerative response following amputation at any stage of its development. Local application of heparan sulfate conjugated beads loaded with fibroblast growth factor-2 (FGF-2) onto an amputated stage 25 chick limb bud results in a high frequency (88%) of limbs in which the regeneration of digit-like structures was induced. The regenerative response is associated with the location of the FGF-2-loaded beads on the limb stump. This is the first report of the induction of a regenerative response in a higher vertebrate limb by a chemically defined agent.

authors

• Muneoka, Ken

published proceedings

• Dev Biol

altmetric score

• 6

author list (cited authors)

• Taylor, G. P., Anderson, R., Reginelli, A. D., & Muneoka, K.

citation count

• 70

complete list of authors

• Taylor, GP||Anderson, R||Reginelli, AD||Muneoka, K

publication date

• January 1994

publisher

• Elsevier  Publisher

published in

• Developmental Biology  Journal

keywords

• Animals
• Bone Regeneration
• Chick Embryo
• Extremities
• Fibroblast Growth Factor 2

Digital Object Identifier (DOI)

• 10.1006/dbio.1994.1144

start page

• 282

end page

• 284

volume

• 163

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1006%2Fdbio.1994.1144