FGF-2 induces regeneration of the chick limb bud. Academic Article uri icon


  • The chick limb bud is unable to mount a regenerative response following amputation at any stage of its development. Local application of heparan sulfate conjugated beads loaded with fibroblast growth factor-2 (FGF-2) onto an amputated stage 25 chick limb bud results in a high frequency (88%) of limbs in which the regeneration of digit-like structures was induced. The regenerative response is associated with the location of the FGF-2-loaded beads on the limb stump. This is the first report of the induction of a regenerative response in a higher vertebrate limb by a chemically defined agent.

published proceedings

  • Dev Biol

altmetric score

  • 6

author list (cited authors)

  • Taylor, G. P., Anderson, R., Reginelli, A. D., & Muneoka, K.

citation count

  • 70

complete list of authors

  • Taylor, GP||Anderson, R||Reginelli, AD||Muneoka, K

publication date

  • January 1994