The mouse digit tip: from wound healing to regeneration.
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A challenge to the study of regeneration is determining at what point the processes of wound healing and regeneration diverge. The mouse displays level-specific regeneration responses. An amputation through the distal third of the terminal phalanx will prompt a regeneration response and result in a new digit tip that mimics the morphology of the lost digit tip. Conversely, an amputation through the distal third of the intermediate phalanx initiates a wound healing and scarring response. The mouse, therefore, provides a model for studying the transition between wound healing and regeneration in the same animal. This chapter details the methods used in the study of mammalian digit regeneration, including a method to introduce exogenous protein into the mouse digit amputation model via microcarrier beads and methods for analysis of bone regeneration.
author list (cited authors)
Simkin, J., Han, M., Yu, L., Yan, M., & Muneoka, K.
complete list of authors
Simkin, Jennifer||Han, Manjong||Yu, Ling||Yan, Mingquan||Muneoka, Ken