Aptamer-targeted DNA nanostructures for therapeutic delivery. Academic Article

abstract

• DNA-based nanostructures have been widely used in various applications due to their structural diversity, programmability, and uniform structures. Their intrinsic biocompatibility and biodegradability further motivates the investigation of DNA-based nanostructures as delivery vehicles. Incorporating AS1411 aptamers into DNA pyramids leads to enhanced intracellular uptake and selectively inhibits the growth of cancer cells, achieved without the use of transfection reagents. Furthermore, aptamer-displaying pyramids are found to be substantially more resistant to nuclease degradation than single-stranded aptamers. These findings, along with their modularity, reinforce the potential of DNA-based nanostructures for therapeutic applications.

authors

• Charoenphol, Phapanin

published proceedings

• Mol Pharm

altmetric score

• 3

author list (cited authors)

• Charoenphol, P., & Bermudez, H.

citation count

• 106

complete list of authors

• Charoenphol, Phapanin||Bermudez, Harry

publication date

• May 2014

publisher

• American Chemical Society (ACS)  Publisher

published in

• Molecular Pharmaceutics  Journal

keywords

• Aptamers, Nucleotide
• DNA
• Drug Carriers
• Drug Delivery Systems
• Hela Cells
• Humans
• Nanomedicine
• Nanostructures
• Oligodeoxyribonucleotides

PubMed Central ID

• 24739136

Digital Object Identifier (DOI)

• 10.1021/mp500047b

start page

• 1721

end page

• 1725

volume

• 11

issue

• 5

URL

• http%3A%2F%2Fdx.doi.org%2F10.1021%2Fmp500047b