Chronic binge alcohol consumption during pregnancy alters rat maternal uterine artery pressure response. Academic Article uri icon

abstract

  • We aimed to investigate pressure-dependent maternal uterine artery responses and vessel remodeling following gestational binge alcohol exposure. Two groups of pregnant rats were used: the alcohol group (28.5% wt/v, 6.0g/kg, once-daily orogastric gavage in a binge paradigm between gestational day (GD) 5-19) and pair-fed controls (isocalorically matched). On GD20, excised, pressurized primary uterine arteries were studied following equilibration (60mm Hg) using dual chamber arteriograph. The uterine artery diameter stabilized at 20mm Hg, showed passive distension at 40mm Hg, and redeveloped tone at 60mm Hg. An alcohol effect (P=0.0025) was observed on the percent constriction of vessel diameter with greater pressure-dependent myogenic constriction. Similar alcohol effect was noted with lumen diameter response (P=0.0020). The percent change in media:lumen ratio was higher in the alcohol group (P<0.0001). Thus, gestational alcohol affects pressure-induced uterine artery reactivity, inward-hypotrophic remodeling, and adaptations critical for nutrient delivery to the fetus.

published proceedings

  • Alcohol

author list (cited authors)

  • Naik, V. D., Lunde-Young, E. R., Davis-Anderson, K. L., Orzabal, M., Ivanov, I., & Ramadoss, J.

citation count

  • 6

complete list of authors

  • Naik, Vishal D||Lunde-Young, Emilie R||Davis-Anderson, Katie L||Orzabal, Marcus||Ivanov, Ivan||Ramadoss, Jayanth

publication date

  • January 1, 1999 11:11 AM