Tamoxifen affects the toxicokinetics of o,p'-DDT in male Nile Tilapia (Oreochromis niloticus). Academic Article

abstract

• The goal of the present study was to evaluate the role of Tamoxifen (TAM), in the distribution and/or elimination kinetics of o,p'-DDT, in male tilapias. A non-compartmental analysis was chosen to describe the time course of o,p'-DDT plasma concentrations. Mean plasma concentration of o,p'-DDT following IP administration indicates a very complex kinetic profile. Tamoxifen decreased the o,p'-DDT mean half-life (t) from 20.38 to 16.11days, the Mean Residence Time (MRT) from 28.7 to 23.23days, and clearance (CL) from 0.0031 to 0.001mL/min. The distribution pattern of o,p'-DDT in tissues and the clearance in plasma suggest that storage points mediated through the membrane-receptor lipophilicity can be involved.

authors

• Gold Bouchot, Gerardo

published proceedings

• Bull Environ Contam Toxicol

author list (cited authors)

• Del Roco Barreto-Castro, M., Gmez-Martnez, L. E., & Gold-Bouchot, G.

citation count

• 1

complete list of authors

• Del Rocío Barreto-Castro, María||Gómez-Martínez, Lisbeth Enith||Gold-Bouchot, Gerardo

publication date

• January 2010

publisher

• Springer Nature  Publisher

published in

• BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY  Journal

keywords

• Animals
• Cichlids
• DDT
• Endocrine Disruptors
• Half-Life
• Male
• Metabolic Clearance Rate
• Selective Estrogen Receptor Modulators
• Tamoxifen
• Tissue Distribution

PubMed Central ID

• 21079915

Digital Object Identifier (DOI)

• 10.1007/s00128-010-0139-1

start page

• 545

end page

• 549

volume

• 85

issue

• 6

URL

• http://dx.doi.org/10.1007/s00128-010-0139-1