Endotoxemia and Glutamine Chapter uri icon


  • © Springer Science+Business Media New York 2015. Endotoxemia markedly modifies glutamine metabolism in several tissues with a decrease of intestinal glutamine uptake and metabolism, and decreased oxygen consumption. In liver, endotoxemia decreases glutamine content and mitochondrial oxygen consumption while in skeletal muscles, it increases glutamine synthesis and release resulting in decreased muscle glutamine content. In lungs, endotoxemia decreased glutamine uptake with increased glutamine synthesis and release. Mostly from endotoxemic animal model experiments (and much less frequently from clinical studies), it appears that supplementation with glutamine in its free or dipeptidic form moderates the increment of the intestinal permeability and bacterial translocation, decreases intestinal inflammation and increases the intestinal microcirculation. In the lung, glutamine supplementation attenuates inflammation and injury. It thus appears that the the rationale for oral glutamine supplementation is relatively strong, as long as the intestinal amino acid absorptive capacity is preserved.

author list (cited authors)

  • Blachier, F., Kong, X., Wu, G., Tomé, D., Lancha, A., Andriamihaja, M., & Yin, Y.

citation count

  • 0

Book Title

  • Glutamine in Clinical Nutrition

publication date

  • January 2015