Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health Academic Article uri icon


  • Osteoarthritis (OA) is a common form of arthritis in humans. It has long been regarded as a non-inflammatory disease, but a degree of inflammation is now recognized as being a vital inducer of subpopulation of OA. Besides inflammation, the establishment and development of OA are associated with alterations in metabolism and profiles of amino acids (AA), including glutamate- and arginine-family AA as well as their related metabolites (e.g., creatinine, hydroxyproline, γ-aminobutyrate, dimethylarginines and homoarginine). Functional AA (e.g., glutamine, arginine, glutamate, glycine, proline, and tryptophan) have various benefits (i.e., anti-inflammation and anti-oxidation) in treatment of inflammation-associated diseases, including OA. Thus, these AA have potential as immunomodulatory nutrients for patients with inflammation-induced OA.

altmetric score

  • 1.85

author list (cited authors)

  • Li, Y., Xiao, W., Luo, W., Zeng, C., Deng, Z., Ren, W., Wu, G., & Lei, G.

citation count

  • 28
  • 30

publication date

  • January 2016