Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health. Academic Article

abstract

• Osteoarthritis (OA) is a common form of arthritis in humans. It has long been regarded as a non-inflammatory disease, but a degree of inflammation is now recognized as being a vital inducer of subpopulation of OA. Besides inflammation, the establishment and development of OA are associated with alterations in metabolism and profiles of amino acids (AA), including glutamate- and arginine-family AA as well as their related metabolites (e.g., creatinine, hydroxyproline, -aminobutyrate, dimethylarginines and homoarginine). Functional AA (e.g., glutamine, arginine, glutamate, glycine, proline, and tryptophan) have various benefits (i.e., anti-inflammation and anti-oxidation) in treatment of inflammation-associated diseases, including OA. Thus, these AA have potential as immunomodulatory nutrients for patients with inflammation-induced OA.

authors

• Wu, Guoyao

published proceedings

• Amino Acids

altmetric score

• 1.85

author list (cited authors)

• Li, Y., Xiao, W., Luo, W., Zeng, C., Deng, Z., Ren, W., Wu, G., & Lei, G.

citation count

• 47

complete list of authors

• Li, Yusheng||Xiao, Wenfeng||Luo, Wei||Zeng, Chao||Deng, Zhenhan||Ren, Wenkai||Wu, Guoyao||Lei, Guanghua

publication date

• April 2016

publisher

• Springer Nature  Publisher

published in

• Amino Acids  Journal

keywords

• Arginine
• Creatinine
• Gamma-Aminobutyric Acid
• Glutamate
• Glutamic Acid
• Glutamine
• Homoarginine
• Humans
• Hydroxyproline
• Immunologic Factors
• Inflammation
• Nutritional Requirements
• Nutritional Status
• Osteoarthritis
• Proline
• Tryptophan

PubMed Central ID

• 26767374

Digital Object Identifier (DOI)

• 10.1007/s00726-015-2168-x

start page

• 907

end page

• 914

volume

• 48

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1007%2Fs00726-015-2168-x

user-defined tag

• 3 Good Health and Well-Being