A case study representing signal transduction in liver cells as a feedback control problem
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A case study was presented in which a signal transduction pathway involved in the body's response to inflammation or injury, was represented as a block diagram, and linear transfer function models were identified in individual blocks for perturbations of the model. The system behavior was broken up into four components, and each part represented the effect a change in the concentration of one component has on others present in the signal transduction pathway. In order to identify the transfer functions, the cell is assumed to be at steady state with a constant input of 3.OE-4 nM of IL-6, resulting in a concentration of the phosphorylated receptor complex of 6.973E-4 nM, a concentration of SOCS3 of 0.1047 nM, and a concentration the nuclear STAT3 dimer of 0.1048 nM. It was found that our identified model appropriately described the behavior of the SOCS3 knockout cell in this way.
author list (cited authors)
Singh, A., Jayaraman, A., & Hahn, J.