Resistance training dose response in combined endurance-resistance training in patients with cardiovascular disease: a randomized trial.
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OBJECTIVE: To compare the effectiveness of 2 different volumes of resistance training (RT) combined with aerobic training in residential cardiac rehabilitation (CR). DESIGN: Randomized prospective cohort study. SETTING: Center for inpatient CR. PARTICIPANTS: Patients (N=295) with a mean age SD of 62.711.7 years participated in the study. INTERVENTIONS: Patients were randomly divided into 2 groups (group 1 and group 2) with different volumes of RT; 2 sets 12 repetitions (REPS) (group 1) and 3 sets 15 REPS (group 2) per session, 2 times per week; each RT session consisting of 10 different resistance exercises. In addition, patients also completed continuous moderate intensity aerobic training composed of cycle ergometry 6 times per week for 174 minutes (mean SD) and walking 5 times per week for 45 minutes. MAIN OUTCOME MEASURES: At entry and after 264 (mean SD) days of CR, blood pressure, heart rate, maximal oxygen consumption, and maximal power determined during cycle ergometry, strength determined via RT, and blood biochemistries were assessed. Data were analyzed via a 2-way (group time) repeated measures analysis of variance. RESULTS: Statistical analysis revealed equivalent improvements in exercise capacity, muscular strength, hemodynamics, and blood chemistries regardless of RT volume (comparison-wise type I error rate, <.01). CONCLUSIONS: Our results show that nearly doubling (3 sets 15 REPS vs 2 sets 12 REPS) the volume of RT as part of a residential CR program does not yield further improvement in strength and cardiovascular risk factors.
