Acute exercise and training alter blood lipid and lipoprotein profiles differently in overweight and obese men and women. Academic Article uri icon


  • Our purpose was to elucidate effects of acute exercise and training on blood lipids-lipoproteins, and high-sensitivity C-reactive protein (hsCRP) in overweight/obese men (n = 10) and women (n = 8); age, BMI, body fat percentage, and VO(2)max were (mean SEM): 45 2.5 years, 31.9 1.4 kgm(-2), 41.1 1.5%, and 25.2 1.3 mlO(2)kg(-1)min(-1). Before exercise training subjects performed an acute exercise session on a treadmill (70% VO(2)max, 400 kcal energy expenditure), followed by 12 weeks of endurance exercise training (land-based or aquatic-based treadmill): 3 sessionsweek(-1), progressing to 500 kcalsession(-1) during which subjects maintained accustomed dietary habits. After training, the acute exercise session was repeated. Blood samples, obtained immediately before and 24 h after acute exercise sessions, were analyzed for serum lipids, lipoproteins, and hsCRP adjusted for plasma volume shifts. Exercise training increased VO(2)max (+3.67 mlO(2)kg(-1)min(-1), P < 0.001) and reduced body weight (-2.7 kg, P < 0.01). Training increased high-density lipoprotein (HDL) and HDL(2b)-cholesterol (HDL-C) concentrations (+3.7 and +2.4 mgdl(-1), P < 0.05) and particle numbers (+588 and +206 nmoll(-1), P < 0.05) in men. In women despite no change in total HDL-C, subfractions shifted from HDL(3)-C (-3.2, P < 0.01) to HDL(2b)-C (+3.5, P < 0.05) and HDL(2a)-C (+2.2 mgdl(-1), P < 0.05), with increased HDL(2b) particle number (+313 nmoll(-1), P < 0.05). Training reduced LDL(3) concentration and particle number in women (-1.6 mgdl(-1) and -16 nmoll(-1), P < 0.05). Acute exercise reduced the total cholesterol (TC): HDL-C ratio in men (-0.16, P < 0.01) and increased hsCRP in all subjects (+0.05 mgdl(-1), P < 0.05), regardless of training. Training did not affect acute exercise responses. Our data support the efficacy of endurance training, without dietary intervention, to elicit beneficial changes in blood lipids-lipoproteins in obese men and women.

published proceedings

  • Obesity (Silver Spring)

altmetric score

  • 11.43

author list (cited authors)

  • Greene, N. P., Martin, S. E., & Crouse, S. F.

citation count

  • 59

complete list of authors

  • Greene, Nicholas P||Martin, Steven E||Crouse, Stephen F

publication date

  • August 2012