Chromosomal assignments for the equine AMPK family genes.
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abstract
5-AMP-activated protein kinase (AMPK), comprised of a catalytic -subunit and non-catalytic - and -subunits, plays a pivotal role in the regulation of cellular energy homeostasis. 1The PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 and PRKAG3 genes encode the seven possible subunits of a functional mammalian AMPK heterotrimer. We derived over 70% of the coding sequence of each equine AMPK subunit gene and determined their chromosomal locations by radiation hybrid mapping and fluorescence in situ hybridization (FISH). 2006 International Society for Animal Genetics.