DNA sensor for sequencing and mismatches based on electron transport through Watson-Crick and non-Watson-Crick base pairs

abstract

• A combined density functional theory and Green's function procedure is used to calculate the electrical characteristics of Watson-Crick and non-Watson-Crick base pairs; calculations are performed to determine: the molecular orbitais that participate in the electron-transfer process, junction current-voltage characteristics, density of states, transmission function, and molecular electrostatic potentials. The distinct current-voltage features of base pairs can be used for detecting and sequencing DNA, as well as for detecting DNA base-pair mismatches by passing the double strand through two perpendicular metallic electrodes to the DNA, or by scanning the double strand with conducting probes. We find in the range from -1 to 1 V for the Watson-Crick pairs that the CG is a better electron conductor than the AT and, on the other hand, the best and worst conductors are the non-Watson-Crick mismatches CT and AA, respectively. 2008 IEEE.

authors

• Seminario, Jorge

published proceedings

• IEEE SENSORS JOURNAL

author list (cited authors)

• Jauregui, L. A., & Seminario, J. M.

citation count

• 21

complete list of authors

• Jauregui, Luis A||Seminario, Jorge M

publication date

• June 2008

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

published in

• IEEE Sensors Journal  Journal

keywords

• DNA Sequencing
• Molecular Electronics
• Molecular Electrostatic Potential (mep)
• Nanotechnology

Digital Object Identifier (DOI)

• 10.1109/JSEN.2008.923232

start page

• 803

end page

• 814

volume

• 8

issue

• 5-6

URL

• http%3A%2F%2Fdx.doi.org%2F10.1109%2Fjsen.2008.923232