Silicate cross-linked bio-nanocomposite hydrogels from PEO and chitosan. Academic Article

abstract

• The compositions and the multi phase structures of bio-nanocomposite hydrogels made from silicate cross-linked PEO and chitosan are related to some of their physical and biological properties. The gels are injectable and self-healing because the cross-linking is physical and reversible under deformation. The presence of chitosan aggregates affects the viscoelastic properties and reinforces the hydrogel network. The chitosan adds advantageous properties to the hydrogel such as enhanced cell spreading and adhesion. In vitro biocompatibility data indicate that NIH 3T3 fibroblasts grow and proliferate on the bio-nanocomposite hydrogel as well as on hydrogel films.

authors

• Gaharwar, Akhilesh

published proceedings

• Macromol Biosci

author list (cited authors)

• Jin, Q. u., Schexnailder, P., Gaharwar, A. K., & Schmidt, G.

citation count

• 40

complete list of authors

• Jin, Qu||Schexnailder, Patrick||Gaharwar, Akhilesh K||Schmidt, Gudrun

publication date

• October 2009

publisher

• Wiley  Publisher

published in

• Macromolecular Bioscience  Journal

keywords

• Animals
• Biocompatible Materials
• Cell Adhesion
• Chitosan
• Cross-Linking Reagents
• Humans
• Hydrogels
• Materials Testing
• Mice
• NIH 3T3 Cells
• Nanocomposites
• Polyethylene Glycols
• Rheology
• Shear Strength
• Silicates
• Surface Properties
• Viscoelastic Substances

PubMed Central ID

• 19593783

Digital Object Identifier (DOI)

• 10.1002/mabi.200900080

start page

• 1028

end page

• 1035

volume

• 9

issue

• 10

URL

• http%3A%2F%2Fdx.doi.org%2F10.1002%2Fmabi.200900080