Physically crosslinked nanocomposites from silicate-crosslinked PEO: mechanical properties and osteogenic differentiation of human mesenchymal stem cells. Academic Article

abstract

• The mechanical and biological properties of silicate-crosslinked PEO nanocomposites are studied. A strong correlation is observed between silicate concentration and mechanical properties. In vitro cell culture studies reveal that an increase in silicate concentration enhances the attachment and proliferation of human mesenchymal stem cells significantly. An upregulation in the expression of osteocalcin on nanocomposites compared to the tissue culture polystyrene control is observed. Together, these results suggest that silicate-based nanocomposites are bioactive and have the potential to be used in a range of biotechnological and biomedical applications such as injectable matrices, biomedical coatings, drug delivery, and regenerative medicine.

authors

• Gaharwar, Akhilesh

published proceedings

• Macromol Biosci

altmetric score

• 0.25

author list (cited authors)

• Gaharwar, A. K., Kishore, V., Rivera, C., Bullock, W., Wu, C., Akkus, O., & Schmidt, G.

citation count

• 106

complete list of authors

• Gaharwar, Akhilesh K||Kishore, Vipuil||Rivera, Christian||Bullock, Whitney||Wu, Chia-Jung||Akkus, Ozan||Schmidt, Gudrun

publication date

• June 2012

publisher

• Wiley  Publisher

published in

• Macromolecular Bioscience  Journal

keywords

• Cell Adhesion
• Cell Differentiation
• Cell Proliferation
• Drug Delivery Systems
• Gene Expression Regulation
• Humans
• Mesenchymal Stem Cells
• Nanocomposites
• Osteocalcin
• Osteogenesis
• Polystyrenes
• Silicates

PubMed Central ID

• 22517665

Digital Object Identifier (DOI)

• 10.1002/mabi.201100508

start page

• 779

end page

• 793

volume

• 12

issue

• 6

URL

• http%3A%2F%2Fdx.doi.org%2F10.1002%2Fmabi.201100508