Photocrosslinkable and elastomeric hydrogels for bone regeneration. Academic Article uri icon


  • Nanocomposite biomaterials are extensively investigated for cell and tissue engineering applications due their unique physical, chemical and biological characteristics. Here, we investigated the mechanical, rheological, and degradation properties of photocrosslinkable and elastomeric nanocomposite hydrogels from nanohydroxyapatite (nHAp) and gelatin methacryloyl (GelMA). The addition of nHAp resulted in a significant increase in mechanical stiffness and physiological stability. Cells readily adhere and proliferate on the nanocomposite surfaces. Cyclic stretching of cells on the elastomeric nanocomposites revealed that nHAp elicited a stronger alignment response in the direction of strain. In vitro studies highlight enhanced bioactivity of nanocomposites as determined by alkaline phosphate (ALP) activity. Overall, the elastomeric and photocrosslinkable nanocomposite hydrogels can be used for minimally invasive therapy for bone regeneration.

published proceedings

  • J Biomed Mater Res A

altmetric score

  • 2.35

author list (cited authors)

  • Thakur, T., Xavier, J. R., Cross, L., Jaiswal, M. K., Mondragon, E., Kaunas, R., & Gaharwar, A. K.

citation count

  • 61

complete list of authors

  • Thakur, Teena||Xavier, Janet R||Cross, Lauren||Jaiswal, Manish K||Mondragon, Eli||Kaunas, Roland||Gaharwar, Akhilesh K

publication date

  • April 2016