A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations.
- Additional Document Info
- View All
A systematic literature review of cystic echinoccocosis (CE) frequency and symptoms was conducted. Studies without denominators, original data, or using one serological test were excluded. Random-effect log-binomial models were run for CE frequency and proportion of reported symptoms where appropriate. A total of 45 and 25 articles on CE frequency and symptoms met all inclusion criteria. Prevalence of CE ranged from 1% to 7% in community-based studies and incidence rates ranged from 0 to 32 cases per 100,000 in hospital-based studies. The CE prevalence was higher in females (Prevalence Proportion Ratio: 1.35 [95% Bayesian Credible Interval: 1.16-1.53]) and increased with age. The most common manifestations of hepatic and pulmonary CE were abdominal pain (57.3% [95% confidence interval [CI]: 37.3-76.1%]) and cough (51.3% [95% CI: 35.7-66.7%]), respectively. The results are limited by the small number of unbiased studies. Nonetheless, the age/gender prevalence differences could be used to inform future models of CE burden.
author list (cited authors)
Budke, C. M., Carabin, H., Ndimubanzi, P. C., Nguyen, H., Rainwater, E., Dickey, M., ... Qian, M.
complete list of authors
Budke, Christine M||Carabin, Hélène||Ndimubanzi, Patrick C||Nguyen, Hai||Rainwater, Elizabeth||Dickey, Mary||Bhattarai, Rachana||Zeziulin, Oleksandr||Qian, Men-Bao