A systematic review of the literature on cystic echinococcosis frequency worldwide and its associated clinical manifestations. Academic Article uri icon


  • A systematic literature review of cystic echinoccocosis (CE) frequency and symptoms was conducted. Studies without denominators, original data, or using one serological test were excluded. Random-effect log-binomial models were run for CE frequency and proportion of reported symptoms where appropriate. A total of 45 and 25 articles on CE frequency and symptoms met all inclusion criteria. Prevalence of CE ranged from 1% to 7% in community-based studies and incidence rates ranged from 0 to 32 cases per 100,000 in hospital-based studies. The CE prevalence was higher in females (Prevalence Proportion Ratio: 1.35 [95% Bayesian Credible Interval: 1.16-1.53]) and increased with age. The most common manifestations of hepatic and pulmonary CE were abdominal pain (57.3% [95% confidence interval [CI]: 37.3-76.1%]) and cough (51.3% [95% CI: 35.7-66.7%]), respectively. The results are limited by the small number of unbiased studies. Nonetheless, the age/gender prevalence differences could be used to inform future models of CE burden.

published proceedings

  • Am J Trop Med Hyg

altmetric score

  • 3.25

author list (cited authors)

  • Budke, C. M., Carabin, H., Ndimubanzi, P. C., Nguyen, H., Rainwater, E., Dickey, M., ... Qian, M.

citation count

  • 110

complete list of authors

  • Budke, Christine M||Carabin, Hélène||Ndimubanzi, Patrick C||Nguyen, Hai||Rainwater, Elizabeth||Dickey, Mary||Bhattarai, Rachana||Zeziulin, Oleksandr||Qian, Men-Bao

publication date

  • June 2013