Growth hormone acutely decreases type III iodothyronine deiodinase in chicken liver. Academic Article

abstract

• Growth hormone (GH) increases plasma T3 and decreases plasma T4 in 18-day old chicken embryos, in newly hatched chicks and in adult chickens within 2 h after injection. The in vivo increase in T3 can be linked to an increased in vitro T3 recovery from liver homogenates incubated with T4. Specific type I and type III deiodinase tests (5'D-I and 5D-III), however, show that GH has no effect at all on the amount of hepatic type I enzyme (catalyzing T4 deiodination to T3) but acutely decreases the amount of type III enzyme (catalyzing T3 deiodination). This suggests that the GH-induced increase in plasma T3 is not due to an increased T3 production, but is the result of a decreased T3 breakdown. The lack of a stimulatory effect of GH injection in 3-day-old fed chicks might be the combined result of a low hepatic type III enzyme level and a low GH receptor availability at that stage.

authors

• Berghman, Luc

published proceedings

• FEBS Lett

author list (cited authors)

• Darras, V. M., Berghman, L. R., Vanderpooten, A., & Khn, E. R.

citation count

• 54

complete list of authors

• Darras, VM||Berghman, LR||Vanderpooten, A||Kühn, ER

publication date

• September 1992

publisher

• Wiley  Publisher

published in

• FEBS Letters  Journal

keywords

• Animals
• Chick Embryo
• Chickens
• Growth Hormone
• Iodide Peroxidase
• Liver
• Radioimmunoassay
• Receptors, Somatotropin
• Thyroxine
• Triiodothyronine

PubMed Central ID

• 1526283

Digital Object Identifier (DOI)

• 10.1016/0014-5793(92)81133-7

start page

• 5

end page

• 8

volume

• 310

issue

• 1

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F0014-5793%2892%2981133-7