Disappearance rate of glycosylated and non-glycosylated chicken growth hormone: influence on biological activity. Academic Article uri icon

abstract

  • The disappearance rates for glycosylated (GcGH) and non-glycosylated chicken growth hormone (NGcGH) were compared following their intravenous injection into anaesthetized adult laying hens. The metabolic clearance rate of GcGH was about 20% lower (P = 0.13) compared to NGcGH. Similarly, there was a tendency towards a longer half-life for GcGH. No major physiological significance could be attributed to the glycosylation state of the preparations as far as their effects on circulating insulin-like growth factor I and iodohormone levels were concerned.

published proceedings

  • Comp Biochem Physiol Pharmacol Toxicol Endocrinol

altmetric score

  • 3

author list (cited authors)

  • Berghman, L. R., Buyse, J., Huybrechts, L. M., Darras, V. M., Vandesande, F., Khn, E. R., Decuypere, E., & Scanes, C. G.
  • Berghman, L. R., Buyse, J., Huybrechts, L. M., Darras, V. M., Vandesande, F., Kühn, E. R., Decuypere, E., & Scanes, C. G
  • Berghman, L. R., Buyse, J., Huybrechts, L. M., Darras, V. M., Vandesande, F., Kühn, E. R., Decuypere, E., & Scanes, C. G.

citation count

  • 8

complete list of authors

  • Berghman, LR||Buyse, J||Huybrechts, LM||Darras, VM||Vandesande, F||Kühn, ER||Decuypere, E||Scanes, CG

publication date

  • July 1994