Disappearance rate of glycosylated and non-glycosylated chicken growth hormone: influence on biological activity. Academic Article

abstract

• The disappearance rates for glycosylated (GcGH) and non-glycosylated chicken growth hormone (NGcGH) were compared following their intravenous injection into anaesthetized adult laying hens. The metabolic clearance rate of GcGH was about 20% lower (P = 0.13) compared to NGcGH. Similarly, there was a tendency towards a longer half-life for GcGH. No major physiological significance could be attributed to the glycosylation state of the preparations as far as their effects on circulating insulin-like growth factor I and iodohormone levels were concerned.

authors

• Berghman, Luc

published proceedings

• Comp Biochem Physiol Pharmacol Toxicol Endocrinol

altmetric score

• 3

author list (cited authors)

• Berghman, L. R., Buyse, J., Huybrechts, L. M., Darras, V. M., Vandesande, F., Khn, E. R., Decuypere, E., & Scanes, C. G.

citation count

• 8

complete list of authors

• Berghman, LR||Buyse, J||Huybrechts, LM||Darras, VM||Vandesande, F||Kühn, ER||Decuypere, E||Scanes, CG

publication date

• July 1994

publisher

• Elsevier  Publisher

published in

• Comparative Biochemistry and Physiology - Part C: Comparative Pharmacology and Toxicology  Journal

keywords

• Analysis Of Variance
• Animals
• Chickens
• Chromatography, Affinity
• Female
• Glycosylation
• Growth Substances
• Half-Life
• Injections, Intravenous
• Insulin-Like Growth Factor I
• Metabolic Clearance Rate
• Radioimmunoassay
• Thyroxine
• Triiodothyronine

PubMed Central ID

• 7981978

Digital Object Identifier (DOI)

• 10.1016/1367-8280(94)90027-2

start page

• 161

end page

• 169

volume

• 108

issue

• 2

URL

• http%3A%2F%2Fdx.doi.org%2F10.1016%2F1367-8280%2894%2990027-2