Investigation of nutrient feeding strategies in a countercurrent mixed-acid multi-staged fermentation: experimental data. Academic Article

abstract

• Nutrients are essential for microbial growth and metabolism in mixed-culture acid fermentations. Understanding the influence of nutrient feeding strategies on fermentation performance is necessary for optimization. For a four-bottle fermentation train, five nutrient contacting patterns (single-point nutrient addition to fermentors F1, F2, F3, and F4 and multi-point parallel addition) were investigated. Compared to the traditional nutrient contacting method (all nutrients fed to F1), the near-optimal feeding strategies improved exit yield, culture yield, process yield, exit acetate-equivalent yield, conversion, and total acid productivity by approximately 31%, 39%, 46%, 31%, 100%, and 19%, respectively. There was no statistical improvement in total acid concentration. The traditional nutrient feeding strategy had the highest selectivity and acetate-equivalent selectivity. Total acid productivity depends on carbon-nitrogen ratio.

authors

• Holtzapple, Mark

published proceedings

• Appl Biochem Biotechnol

author list (cited authors)

• Smith, A. D., Lockman, N. A., & Holtzapple, M. T.

citation count

• 10

complete list of authors

• Smith, Aaron Douglas||Lockman, Nur Ain||Holtzapple, Mark T

publication date

• June 2011

publisher

• Springer Nature  Publisher

published in

• Applied Biochemistry and Biotechnology  Journal

keywords

• Bioreactors
• Biotechnology
• Carbon
• Carboxylic Acids
• Fermentation
• Nitrogen
• Solubility
• Temperature

PubMed Central ID

• 21221842

Digital Object Identifier (DOI)

• 10.1007/s12010-010-9145-3

start page

• 426

end page

• 442

volume

• 164

issue

• 4

URL

• http%3A%2F%2Fdx.doi.org%2F10.1007%2Fs12010-010-9145-3